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ProTIDol

Validazione di un prodotto terapeutico innovativo per la gestione del dolore cronico primario limitando l’infiammazione persistente e la neuroinfiammazione associate
Classification: 
national research
Programme: 
PO FESR Sicilia 2014-2020
Call: 
Avviso pubblico relativo all’Azione 1.1.5
Main ERC field: 
Life Sciences
Unict role: 
Partner
Duration (months): 
30
Start date: 
Friday, December 20, 2019
End date: 
Saturday, September 30, 2023
Total cost: 
€ 3.660.160,00
Unict cost: 
€ 1.583.600,00
Coordinator: 
EPITECH GROUP s.p.a.
Principal investigator in Unict: 
Prof. Mario Zappia
University department involved: 
Department of Chemical Sciences
Department of Medical and Surgical Sciences and advanced technologies
Participants: 

Università di Messina

Abstract

The general objective of the research project is to develop a prototype of a product based on a PEA derivative, to be used to counteract persistent inflammatory processes and neuroinflammation associated with chronic pain. It is a natural molecule, inhibitor and modulator of the NAAA (N-acylethanolamine-hydrolyzing acid amidase) enzyme, as well as an endogenous regulator of the endocannabinoid system.

The molecule, protected by an Epitech patent and with co-authors belonging to the University of Messina, is experimentally able to counteract the inflammatory processes associated with painful states and to antagonize neuroinflammation. In terms of social impact, the general objective of the project responds to the urgent need to have innovative tools to combat persistent inflammation and pain with greater effectiveness than available pharmacological therapies and with better safety profiles.